Publications

Selected Publications

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Binge eating, overeating and 'food addiction': Approaches for examining food overconsumption in laboratory rodents.

Brown RM & James, MH. Progress in Neuropsychopharmacology and Biological Psychiatry 2023. PMID 36623582.

Sleep disturbance in substance use disorders: the orexin (hypocretin) system as an emerging pharmacological target

Gyawali U & James, MH. Neuropsychopharmacology 2023. PMID 35931814.

Sleep disruption as a potential contributor to the worsening of eating disorder pathology during the COVID-19 pandemic

Mehr JB & James, MH. Journal of Eating Disorders 2022. PMID 36424635.

Rat anterior cingulate cortex continuously signals decision variables in a patch foraging task

Kane G, James, MH, Shenhav A, Daw, ND, Cohen JD, Aston-Jones G. Journal of Neuroscience 2022. PMID 35688627

Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

Giannotti G, Mottarlini F, Heinsbroek JA, Mandel MR, James MH, Peters J. Translational Psychiatry 2022. PMID: 36195606

Orexin (hypocretin) and addiction

Mehr, J. M., Bilotti, M. M. & James, MH. Trends in Neuroscience 2021. PMID 34642086

Orexin receptor 1 signaling in ventral tegmental area mediates cue driven demand for cocaine

Pantazis, C. B., James, M. H., O'Connor, S. L., Shin, N. Aston-Jones, G. Neuropsychopharmacology 2021. PMID 34635803

A common limiter circuit for opioid choice and relapse identified in a rodent addiction model

Heinsbroek, J., Giannotti, G., Mandel, M. R., Josey, M., Aston-Jones, G., James, M. H., Peters, J. Nature Communications 2021. PMID: 34373454

Sleep dysregulation in binge eating disorder and "food addiction": the orexin (hypocretin) system as a potential neurobiological link

Mehr, J. M., Mitchison, D., Bowrey, H. E. & James, MH. Neuropsychopharmacology 2021. PMID 334145404

Construction of a Virtual Opioid Bioprofile: A Data-Driven QSAR Modeling Study to Identify New Analgesic Opioids

Jia, X., Ciallella, H. L., Russo, D. P., Zhao, L., James, M. H., Zhu. H. ACS Sustain Chem Eng. 2021. PMID: 34239782

The sensation seeking trait confers a dormant susceptibility to addiction that is revealed by intermittent self-administration of cocaine in rats

O'Connor, S. L., Aston-Jones, G. & James, MH. Neuropharmacology 2021. PMID 33862028.

The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse

James, MH, Fragale, JE, O'Connor, SL, Zimmer, BA, & Aston-Jones, G. Neuropharmacology 2021. PMID 33091458

Mimicking human drug consumption patterns in rat engages corticostriatal circuitry

James, MH Neuroscience 2020. PMID 32682655

Intermittent self-administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system.

Fragale, J.E, James, MH & Aston-Jones, G. Addiction Biology 2020, in press

Repurposing the dual orexin receptor antagonist suvorexant for the treatment of opioid use disorder: why sleep on this any longer?

James MH, Fragale JE, Aurora RN, Cooperman NA, Langleben DD, Aston-Jones G. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 2020. PMID 31986520

Sex differences in demand for highly palatable foods: Role of the orexin system.

Freeman L.R., Bentzley B. S., James M. H. & Aston-Jones G.. International Journal of Neuropsychopharmacology 2020. PMID 32496559

Do striatal push/pull circuits hold the key to compulsive, relapsing heroin addiction?

James MH, Mahler SV. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 2020. PMID 31974443

Introduction to the Special Issue: “Making orexin-based therapies for addiction a reality: What are the steps from here?”

James MH, Aston-Jones G Brain Research 2020. PMID 31930996.

The role of orexin-1 receptor signaling in demand for the opioid fentanyl

Fragale JE, Pantazis CB, James MH, Aston-Jones G. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 2019. PMID 31112988

Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats

James MH, Stopper CM, Zimmer BA, Koll NE, Bowrey HE, Aston-Jones G. Biological Psychiatry 2019. PMID 30219208

Orexin-1 receptor signaling in ventral pallidum mediates demand for the opioid remifentanil.

Mohammadkhani A*, Fragale JE*, Pantazis CB, James MH, Aston-Jones G. The Journal of Neuroscience 2019. PMID 31641055

Reduced sensory-evoked locus coeruleus-norepinephrine neural activity in female rats with a history of dietary-induced binge eating.

Bello NT, Yeh C-Y, James MH. Frontiers in Psychology 2019. PMID 31551861

Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.

Yeoh JW*, James MH*, Adams CD, Bains JS, Sakurai T, Aston-Jones G, Dayas CV. Neuropharmacology 2019. PMID 30253175